Éditeur(s) : Food and Resource Economics Dept., Institute of Food and Agricultural Sciences, University of Florida Food and Resource Economics Dept., Institute of Food and Agricultural Sciences, University of Florida ( Gainesville Fla )
Résumé : (Bibliography) Includes bibliographical references.
(Statement of Responsibility) Uma Lele.
"November 1992"--Cover.
"Keynote address to the First Plenary Session of the European Association of Agricultural Economists' Seminar on Food and Agricultural Policies Under Structural Adjustment, September 21-25, 1992, Hohenheim, Germany."
(Funding) Electronic resources created as part of a prototype UF Institutional Repository and Faculty Papers project by the University of Florida.
Africa
Asia
Latin America
Africa
Asia
Latin America

Droits : All rights reserved, Board of Trustees of the University of Florida
001784450
27377053
AJK7832

Éditeur(s) : Université des Antilles et de la Guyane CEREGMIA : Centre d'études et de recherche en économie, gestion et modélisation informatique appliquée Université des Antilles et de la Guyane CEREGMIA : Centre d'études et de recherche en économie, gestion et modélisation informatique appliquée
Résumé : The globalization process, accelerating in the last 20 years, has raised important developmental stakes : on the one hand, economic questions with the multiplication of exchanges and its concentration in certain regions of the world; on the other hand globalization has also raised important social issues, with the acceleration of demographic flux and the whole question of "inclusion" associated with this; the issues are also environmental, through increased needs and resource limitations. Tourism represents the ideal vector of this globalization and the stakes it represents. By focusing on international tourism in a country in the South, this article seeks to better understand the stakes involved in developing international tourism resources, by seeking an answer to the question : In what ways can ecotourism constitute a real strategy for economic development, poverty alleviation, and contribute to economic growth and the protection of natural resources ? We will be examining this question in the context the Ranomafana National Park in Madagascar.

Droits : Document protégé par le droit d'auteur
fichiers:HASH29f953af13018e4196aff5

Éditeur(s) : Londres : T. Woolmer
Siècle(s) traité(s) : 19
Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG18190
ADG18190

Éditeur(s) : Yale University
Résumé : Sea-surface temperature images of the coastal upwelling regions off Northwest Africa show that the core of upwelling is sometimes located far from the coast. This has been documented in three regions that share a common feature, namely a wide and shallow continental shelf. This upwelling feature plays a key role in the ecology of the Canary Current System. It creates an innerfront which provides retention for biological material, e.g. fish eggs and larvae, in the highly productive nearshore environment. An analytical model has been developed based on a two dimensional extension of Ekman's solution. The linear and steady response of a homogeneous ocean forced by an upwelling-favorable wind provides a mechanism for the upwelling separation from the coast. The merging of the surface and bottom Ekman layers induces a very weak cross-shore circulation and a "kinematic barrier" for the Ekman transport divergence. In the case of an alongshore wind, the barrier is located near the isobath h ≈ 0.4D, where D is the thickness of Ekman layers. This yields an upwelling cell which is essentially concentrated in the region 0.5D < h < 1.25D, with upwelling occurring preferentially near the isobath h ≈ 0.6D. It turns out that the cross-shore width of upwelling scales with D/S, the ratio of Ekman depth to bottom topographic slope. The application of this solution to real bathymetric profiles rationalizes, not only the offshore upwelling observations in Northwest Africa, but also the influence of topography on the cross-shelf structure of a wind-driven coastal upwelling. The model also quantifies the effect of the cross-shore wind component showing how it drives the nearshore pressure gradient adjustment and how it affects the upwelling. A linear numerical experiment reproduces the theoretical steady solution, thereby allowing investigation of the transient regime. Relaxation of the hypothesis in the numerical model validates the linear assumption of the theory and then allows investigation of the sensitivity to friction parameterizations and the influence of stratification. The latter leads to an "oscillation" of the upwelling cell with seaward migration driven by outcropping and homogeneization of the water column, and, coastal incursion driven by a "boundary layers splitting" process caused by shoreward advection of the isopycnal dome and stratification of the inner shelf.
Journal of Marine Research (Yale University), 2008-09 , Vol. 66 , N. 5 , P. 589-616

Droits : 2008 Yale University
http://archimer.ifremer.fr/doc/2008/publication-6334.pdf
DOI:10.1357/002224008787536790
http://archimer.ifremer.fr/doc/00000/6334/

Éditeur(s) : New York : The American geographical society
Résumé : 1 fascicule

Droits : Domaine public
Provenance : Université de Nantes. Service commun de la documentation
Permalien : http://www.manioc.org/patrimon/NAN13034
NAN13034

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
OBJECTIVES: The time from the prenatal period through early childhood is an important window of vulnerability for the developing immune and respiratory systems, both sensitive to environmental chemicals such as solvents. This study sought to examine the effects of solvent exposure during the prenatal and postnatal periods on wheezing, eczema and food allergies in early childhood. METHODS: This study, based on the PELAGIE cohort, included 1505 mother-child pairs with measurements of prenatal and postnatal solvent exposures and data on wheezing, eczema or food allergies. The maternal occupation reported at inclusion, in early pregnancy allowed us to define prenatal occupational solvent exposure (by three specific job-exposure matrices). Data on prenatal and postnatal domestic solvent exposure, that is exposure to products that contain solvents, were obtained from self-administered questionnaires, once at inclusion and again when the child was 2 years old. Outcome data was collected at the 2-year follow-up. Associations between exposures and outcomes were estimated by logistic regression models, after adjustment for potential confounders. RESULTS: No association was observed between prenatal exposure to solvents and the outcomes studied. Postnatal exposure was associated with an increased risk of wheezing (OR=1.80 (95% CI 1.25 to 2.59)) which persisted after adjustment for prenatal exposure. No significant association was observed with eczema or food allergies. CONCLUSIONS: Postnatal exposure to solvent-containing products in the home may increase the risk of wheezing in early childhood. Follow-up studies are needed to determine if the health effects observed at age 2 persist at later ages.
ISSN: 1351-0711

hal-01063913
https://hal.archives-ouvertes.fr/hal-01063913
DOI : 10.1136/oemed-2013-102036
PUBMED : 24996679

Éditeur(s) : Université de Bucarest - Université de Bretagne occidentale
Résumé : This study is focusing on the architecture and recent sedimentary evolution of the Danube channel, the youngest channel-levee system in the Danube deep-sea fan. The study was conducted as part of the BlaSON French-Romanian Project, and combined high-resolution seismic-reflection profiles and chirp profiles with multibeam bathymetry and piston cores. This data set was acquired in 1998 during a joint survey IFREMER-GeoEcoMar of the north-western Black Sea. Previous seismic and acoustic data were also used. The Danube deep-sea fan is a large passive-margin mud-rich fan. Like the other systems of this type (Amazon fan, Mississippi fan or Indus fan) the Danube fan consists of stacked channel-levee systems intercalated with mass-transport deposits. Seismic and sedimentary facies in the Danube fan are similar to those identified in most of the mud-rich systems. Nevertheless, the Danube fan is distinguished by a specific feature: its development in a freshwater environment. This is due to the peculiar water-level history of the Black Sea controlled by the link to the Mediterranean through the Strait of Bosphorus and the Sea of Marmara. This connexion was successively interrupted (during sea level lowstands) and re-established (when the sea level was rising above the Bosphorus). Temporary absence of marine water influx during lowstands together with large freshwater inputs from the Danube and other major rivers changed the Black Sea into a freshwater lake during times of fan activity. This peculiarity possibly favourised the development of hyperpycnal flow at the Danube mouth and the initiation of turbidity currents in the deep-sea fan. The Danube channel is directly connected to the large shelf-indenting Danube canyon (also known as Viteaz canyon). The Danube canyon is deeply incised into the shelf margin for 26 km landward of the shelfbreak. During lowstands this canyon acted as the most important path for sediment supply to the deep sea in this part of the continental margin. It consists of a main trough with steep flanks, and a meandering thalweg cut into the flat canyon floor, attesting for the development of the canyon by erosion in the entrenched axial thalweg. Sections with specific morphology, orientation and gradient identified along the canyon, are interpreted as phases of landward expansion of the canyon. Internal structure of the canyon shows several erosional surfaces, which indicate that the present morphology of the canyon is the result of its polyphasic evolution. Instability in the zone of the canyon is related to the important sediment supply at the Danube mouth, to the presence of the gas in the surficial sediment, and possibly under a structural control. The upper part of the Danube channel (between the Danube canyon and ~1400 m depth) consists in a single leveed-channel that has undergone significant overbank deposition, as attested by the well-developed levees. The levees are strongly asymmetrical, being higher and wider on the right-hand side looking downstream. This type of asymmetry is rather common in deep-sea fans, and is generally attributed to the Coriolis effect (Menard, 1955). The channel is slightly sinuous, partially filled and incised by an entrenched thalweg, connected to the axial thalweg of the Danube canyon. Detailed seismic investigation inside the channel trough documented several depositional phases within the channel fill, separated by erosional surfaces. These surfaces are associated with distinct terraces identified on the multibeam bathymetry, that can be followed downward along the main trough axis. The valley fill deposits (where not removed by the subsequent erosional event) show an axial HAR (High Amplitude Reflections) seismic facies with lateral lower amplitude continuous reflections consisting in a levee facies, as proved by sampling. This indicates that filling up was associated with flow within the channel, and not with interruption of fan activity. On the middle slope below 1400 m, this single channel bifurcates through repeated avulsions. As a result, several highly meandering channels developed. The onlap relationships between these channels indicate that only one channel was active at a time. Each phase of avulsion resulted in a depositional unit consisting in a basal unchannelized lobe defined as High Amplitude Reflection Packets (HARP, Flood et al., 1991) that underlies a channel-levee system. The deposition of HARPs was associated with the readjustment of the longitudinal profile of the channel after the breaching of a levee, which resulted in remobilization of upslope channel deposits and eroded levees. When this adjustment was complete, erosion ceased and levees began to develop above the HARPs (Pirmez et al., 1997). All the identified phases of avulsion followed the same pattern: (1) breaching of the lower and narrower left levee; (2) building of a unit of High Amplitude Reflector Packets (HARP) basinward of the bifurcation point by the unchannelized flow, while the former channel was abandoned; and (3) initiation of a new meandering leveed channel. The northward migration of the resulting units through repeated bifurcations is influenced by the asymmetry between levees (hence by the Coriolis effect), and confined between the high levees of the initial phase of the Danube channel (to the south) and the steep relief of the Dniepr fan (to the north). Structure of the fan valley fill indicate that the erosional surfaces inside the upper channel could be formed in response of successive avulsions, by the adjustment of the longitudinal profile of the channel following the breaching of a levee wall. Sediments removed by erosion formed the HARP lobes basinward of the avulsion point. When this adjustment was complete, a channel-levee system developed downward of the bifurcation, overlying the HARPs, but also upward of this point, as a confined channel-levee system inside the erosional trough of the fan valley. Fluvial incisions identified on the continental shelf, together with the coastline location during the last active period of the Danube channel, indicated that the paleo-Danube was directed towards the head of the Danube canyon. Paleo-Danube mouth was fairly close (ca. 10 km) to the Danube canyon, supplying sediment to the Danube channel. Furthermore, hyperpycnal flow probably prevailed in the freshwater environment that characterized the Black Sea during times of fan activity. These conditions would have enabled the development of a quasi-continuous river-canyon-deep-sea fan system, ensuring the effective transfer of the sediment between the coastal zone and the deep sea.
Ce travail est consacré à l'étude de l'architecture et de l'évolution sédimentaire récente de l'éventail profond du Danube, en particulier de son dernier système chenal-levée: le chenal du Danube. L'étude a été réalisée dans le cadre du projet de coopération franco-roumaine BlaSON, à partir des données sismiques, bathymétriques-acoustiques et sédimentologiques acquises en 1998 lors d'une campagne en mer Noire réalisée par IFREMER et GeoEcoMar. Des données sismiques et acoustiques antérieures ont été également utilisées. L'éventail profond du Danube s'enserre dans la catégorie des grands éventails vaseux. Comme les autres systèmes de ce genre (tel que les éventails de l'Amazone, du Mississippi ou de l'Indus) il est constitué d'une succession de systèmes chenaux-levées intercalés avec des dépôts de transport en masse. Le fonctionnement de l'éventail était conditionné par la baisse du niveau marin lors des périodes glaciaires. Ses faciès sismiques et sédimentaires s'apparentent aux faciès qui caractérisent la plupart des éventails de ce type. L'éventail du Danube constitue néanmoins un cas particulier parmi les autres systèmes étudiés, du fait de son fonctionnement dans un bassin lacustre. Ceci est dû à la situation spécifique de la mer Noire dont la connexion avec la Méditerranée, par le détroit de Bosphore et la mer de Marmara, a été successivement interrompue (au cours de périodes de bas niveau) et reprise (quand le niveau marin remontait en dépassant le seuil du Bosphore). L'absence de l'apport d'eau salée pendant les périodes glaciaires, associée avec l'augmentation de l'apport fluvial, ont déterminé l'installation d'un milieu d'eau douce dans la mer Noire à chaque fois que la baisse du niveau permettait la reprise du fonctionnement de l'éventail profond. Cette situation particulière aurait favorisé la formation des courants hyperpycnaux à l'embouchure d'un fleuve du débit du Danube qui déversait ses eaux turbides dans un bassin lacustre, et aurait donc influencé l'apparition de courants de turbidité dans l'éventail profond. Le chenal du Danube s'est développé sur la pente continentale en prolongation du canyon du Danube (ou Viteaz) auquel il est directement connecté. Le canyon est incisé de manière significative (26 km) dans la plate-forme continentale. Au cours de bas-niveaux marins il constituait la principale voie de transfert des sédiments terrigènes vers le bassin profond dans cette partie de la marge. Le canyon est constitué par une entaille avec des flancs abrupts et un talweg axial incisé, qui montre l'importance du processus d'érosion du fond pour le développement du canyon. Les segments qui ont été identifiés le long du canyon, avec des morphologies, des orientations et des pentes spécifiques, sont interprétés comme des phases d'avancement du canyon vers la côte. Plusieurs incisions sont visibles dans la structure interne du canyon et témoignent que la morphologie actuelle du canyon est le résultat de son évolution polyphasée. L'instabilité de la zone du canyon est en relation avec les apports sédimentaires importants à l'embouchure du Danube, avec la présence du gaz dans les sédiments superficiels, et possiblement sous un contrôle structural. Sur la pente supérieure (entre le canyon du Danube et environ 1400 m de profondeur) le chenal du Danube présente des levées bien développées et fortement asymétriques, avec la levée droite plus haute et plus large que la levée gauche. Ce type d'asymétrie, fréquemment décrit dans les éventails profonds est généralement attribué à l'effet Coriolis (Menard, 1955). Le chenal est légèrement sinueux, partiellement comblé et incisé par un talweg axial qui représente la continuation sur la pente du talweg incisé dans le canyon du Danube. L'analyse sismique détaillée du remplissage de la vallée montre plusieurs phases de dépôt, séparées par des discontinuités érosives. Ces surfaces d'érosion correspondent à des terrasses emboîtées, relativement parallèles le long de la vallée, visibles dans la bathymétrie. Les dépôts qui constituent le remplissage du chenal présentent un faciès sismique de type HAR (High Amplitude Reflections) dans l'axe du chenal, partiellement (ou parfois totalement) enlevé par les phases d'érosion subséquentes, qui continue latéralement avec des réflexions litées correspondant à un faciès sédimentaire de levée. Le remplissage de la vallée a été donc associé avec des écoulements dans le chenal, et non pas avec l'interruption de son fonctionnement. Sur la pente inférieure, le chenal unique bifurque plusieurs fois par avulsion et forme de nouveaux systèmes chenaux-levées méandriformes. Ces systèmes se succèdent verticalement en onlap, ce qui montre qu'un seul chenal a été actif à la fois. Chaque phase d'avulsion a eu comme résultat la mise en place d'une unité constituée par un lobe défini comme "High Amplitude Reflection Packets" (HARP, Flood et al., 1991) à la base, et un système chenal-levée au sommet. Le dépôt d'un lobe HARP est associé avec de l'érosion dans le chenal en amont du point d'avulsion pour l'ajustement de son profil après la rupture de la levée. Quand le chenal a retrouvé son profil d'équilibre, l'érosion a cessé et des levées ont commencé à se développer au-dessus des HARPs (Pirmez et al., 1997). Toutes les phases d'avulsion se sont développées d'après le même modèle: (1) la rupture de la levée gauche, plus étroite; (2) le dépôt d'un lobe HARP par les écoulements non-chenalisés en aval du point d'avulsion, et l'abandon de l'ancien chenal; (3) l'initiation d'un nouveau système chenal-levée. La migration systématique du chenal vers le nord est influencée par l'assymétrie des levées (donc par la force de Coriolis), et confinée entre les grandes levées de la phase initiale du chenal du Danube, au sud, et le relief abrupt de l'éventail du Dniepr au nord. La structure sédimentaire du chenal du Danube indique que les surfaces érosives à l'intérieur du remplissage du chenal se seraient formées en réponse aux avulsions, du fait de l'ajustement du profil du chenal après la rupture d'une levée. Les sédiments du chenal érodés au cours de ce processus ont formé les lobes HARP. Quand le chenal a retrouvé son profil d'équilibre, un système chenal-levée s'est développé en aval du point d'avulsion au dessus du lobe HARP, mais aussi en amont de ce point, où il se trouve confiné dans la vallée érosive. Les incisions fluviatiles identifiés sur la plate-forme continentale et la position de la ligne de côte pendant la dernière période d'activité du chenal du Danube montrent que le paléo-Danube se dirigeait directement vers la tête du canyon du Danube. Son embouchure était située à proximité du canyon, qui alimentait le chenal du Danube. Cependant, les courants hyperpycnaux devaient prévaloir dans le milieu de salinité réduite qui caractérisait la mer Noire lors des périodes actives de l'éventail. Ces conditions auraient favorisé la mise en place d'un système quasi-continu fleuve-canyon-éventail profond, qui contrôlait le transfert des sédiments entre la côte et le bassin profond.

Droits : info:eu-repo/semantics/openAccess
http://archimer.ifremer.fr/doc/2002/these-1206.pdf
http://archimer.ifremer.fr/doc/00000/1206/

Éditeur(s) : HAL CCSD IWA Publishing
Résumé : International audience
UV spectrophotometry is largely used for water and wastewater quality monitoring. The measurement/estimation of specific and aggregate parameters such as nitrate and dissolved organic carbon (DOC) is possible with UV spectra exploitation, from 2 to multi wavelengths calibration. However, if nitrate determination from UV absorbance is known, major optical interferences linked to the presence of suspended solids, colloids or dissolved organic matter limit the relevance of UV measurement for DOC assessment. A new method based on UV spectrophotometric measurement of raw samples (without filtration) coupling a dual pathlength for spectra acquisition and the second derivative exploitation of the signal is proposed in this work. The determination of nitrate concentration is carried out from the second derivative of the absorbance at 226 nm corresponding at the inflexion point of nitrate signal decrease. A short optical pathlength can be used considering the strong absorption of nitrate ion around 210 nm. For DOC concentration determination the second derivative absorbance at 295 nm is proposed after nitrate correction. Organic matter absorbing slightly in the 270-330 nm window, a long optical pathlength must be selected in order to increase the sensitivity. The method was tested on several hundred of samples from small rivers of two agricultural watersheds located in Brittany, France, taken during dry and wet periods. The comparison between the proposed method and the standardised procedures for nitrate and DOC measurement gave a good adjustment for both parameters for ranges of 2-100 mg/L NO3 and 1 30 mg/L DOC. (C) 2016 Elsevier Ltd. All rights reserved.
ISSN: 0043-1354

hal-01460742
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01460742
DOI : 10.1016/j.watres.2016.11.010
PUBMED : 27838025

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
The discerning behavior of living systems relies on accurate interactions selected from the lot of molecular collisions occurring in the cell. To ensure the reliability of interactions, binding partners are classically envisioned as finely preadapted molecules, selected on the basis of their affinity in one-step associations. But the counterselection of inappropriate interactions can in fact be much more efficiently obtained through difficult multi-step adjustment, whose final high energy state is locked by a fluctuation ratchet. The progressive addition of molecular bonds during stereo-adjustment can be modeled as a predominantly backward random walk whose first arrival is frozen by a micro-irreversible transition. A new criterion of ligand specificity is presented, that is based on the ratio rejection/incorporation. In addition to its role in the selectivity of interactions, this generic recipe can underlie other important biological phenomena such as the regular synthesis at low level of supramolecular complexes, monostable kinetic bimodality, substrate concentration thresholds or the preparation of rapidly depolymerizable structures with stored energy, like microtubules
ISSN: 0079-6107

hal-01274234
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01274234
DOI : 10.1016/j.pbiomolbio.2016.02.001
PUBMED : 26867859

Éditeur(s) : HAL CCSD BMJ Publishing Group
Résumé : International audience
OBJECTIVE: To investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology. METHODS: ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers) is a French, multicentre, population-based, case-control study. Information on the lifelong work history of 2926 cases and 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents. Solvents were studied separately and in combinations. ORs were computed using unconditional logistic regression models adjusted for classic risk factors, including a history of cigarette smoking and exposure to asbestos. Adjustment for socioeconomic status (SES) was also made. RESULTS: After adjustment for exposure to asbestos, we observed a positive, statistically significant association with lung cancer for men and women exposed to a combination of perchloroethylene (PCE), trichloroethylene and dichloromethane (DCM). Further adjustment for SES slightly decreased this association. In contrast, no statistically significant associations were found for other solvent combinations. CONCLUSIONS: These results suggest that exposure to PCE may constitute a risk factor for lung cancer, especially among women, who seem to have a higher prevalence of exposure than men.
ISSN: 1351-0711

hal-01063908
https://hal.archives-ouvertes.fr/hal-01063908
DOI : 10.1136/oemed-2014-102182
PUBMED : 25015929

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: HIV cohort collaborations, which pool data from diverse patient cohorts, have provided key insights into outcomes of antiretroviral therapy (ART). However, the extent of, and reasons for, between-cohort heterogeneity in rates of AIDS and mortality are unclear. METHODS: We obtained data on adult HIV-positive patients who started ART from 1998 without a previous AIDS diagnosis from 17 cohorts in North America and Europe. Patients were followed up from 1 month to 2 years after starting ART. We examined between-cohort heterogeneity in crude and adjusted (age, sex, HIV transmission risk, year, CD4 count and HIV-1 RNA at start of ART) rates of AIDS and mortality using random-effects meta-analysis and meta-regression. RESULTS: During 61 520 person-years, 754/38 706 (1.9%) patients died and 1890 (4.9%) progressed to AIDS. Between-cohort variance in mortality rates was reduced from 0.84 to 0.24 (0.73 to 0.28 for AIDS rates) after adjustment for patient characteristics. Adjusted mortality rates were inversely associated with cohorts' estimated completeness of death ascertainment [excellent: 96-100%, good: 90-95%, average: 75-89%; mortality rate ratio 0.66 (95% confidence interval 0.46-0.94) per category]. Mortality rate ratios comparing Europe with North America were 0.42 (0.31-0.57) before and 0.47 (0.30-0.73) after adjusting for completeness of ascertainment. CONCLUSIONS: Heterogeneity between settings in outcomes of HIV treatment has implications for collaborative analyses, policy and clinical care. Estimated mortality rates may require adjustment for completeness of ascertainment. Higher mortality rate in North American, compared with European, cohorts was not fully explained by completeness of ascertainment and may be because of the inclusion of more socially marginalized patients with higher mortality risk.
ISSN: 0300-5771

hal-00875138
https://hal.archives-ouvertes.fr/hal-00875138
DOI : 10.1093/ije/dys164
PUBMED : 23148105

Éditeur(s) : Londres : Sampson Law, Marston, Searle & Rivington
Siècle(s) traité(s) : 19
Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG18114
ADG18114

Éditeur(s) : HAL CCSD Oxford University Press (OUP)
Résumé : International audience
BACKGROUND: The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. METHODS: Data were obtained from the International Collaboration on Endocarditis-Prospective Cohort Study of 4794 patients with definite IE who were admitted to 64 centers from June 2000 through December 2006. Multivariate logistic regression and Cox regression analyses were performed to estimate the impact of early surgery on hospital and 1-year mortality after adjustments for other significant covariates. RESULTS: Of the 857 patients with IE complicated by ischemic stroke syndromes, 198 who underwent valve replacement surgery poststroke were available for analysis. Overall, 58 (29.3%) patients underwent early surgical treatment vs 140 (70.7%) patients who underwent late surgical treatment. After adjustment for other risk factors, early surgery was not significantly associated with increased in-hospital mortality rates (odds ratio, 2.308; 95% confidence interval [CI], .942-5.652). Overall, probability of death after 1-year follow-up did not differ between 2 treatment groups (27.1% in early surgery and 19.2% in late surgery group, P = .328; adjusted hazard ratio, 1.138; 95% CI, .802-1.650). CONCLUSIONS: There is no apparent survival benefit in delaying surgery when indicated in IE patients after ischemic stroke. Further observational analyses that include detailed pre- and postoperative clinical neurologic findings and advanced imaging data (eg, ischemic stroke size), may allow for more refined recommendations on the optimal timing of valvular surgery in patients with IE and recent stroke syndromes.
ISSN: 1058-4838

hal-00875143
https://hal.archives-ouvertes.fr/hal-00875143
DOI : 10.1093/cid/cis878
PUBMED : 23074311

Éditeur(s) : HAL CCSD
Résumé : International audience
The Corinth Rift is the most seismically active zone in Europe. Since the year 2000, the Corinth Rift Laboratory (CRL, http://crlab.eu) consisting in a multidisciplinary natural observatory, aims at understanding the mechanics of faulting and earthquake nucleation in the Rift. Recent studies have improved our view about fault geometry and mechanics within CRL but there is still a critical need for a better knowledge of the structure at depth.In this project, we aim to analyze the complete seismological database (13 years of recordings) of CRL by using recently developed methodologies of structural imaging in order to determine, with high resolution, the local 3D structure and the earthquake locations. We perform an iterative joint determination of 3D velocity model and earthquake coordinates. P and S velocity models are estimated through a first arrival traveltime tomography by using the adjoint state method proposed by Taillandier et al. (2009). It consists in the minimization of the cost function between observed and theoretical arrival times,which is achieved by estimating the gradient of the cost function. Earthquake locations are also estimated with a linearized inversion approach by computing the gradient of the misfit function. Iterations are repeated until the cost function no longer decreases. We present preliminary results consisting in: (1) the adjustment of a 1D velocity model that is used as initial model of the 3D tomography and (2) a first attempt of the joint determination of 3D velocity model and earthquake locations.We also perform a preliminary receiver function analysis of teleseismic data recorded by the broadband stations of the CRL network. The multiscale approach (Gesret et. al., 2010) analysis of teleseismic P to S converted waves allows to analyze the signal toward the higher frequencies and thus to characterize the structure at depth with a high resolution. Our multiscale approach should give us reliable depth of interfaces beneath seismometers in the CRL area. In this first attempt, we adjust the 1D velocity model that produces a synthetic RF as similar as possible to the stack of observed RF for a subset of data. The identified interfaces could then be compared with heterogeneities imaged by the tomography.
AGU Fall Meeting
San Fransico, United States

hal-01417184
https://hal-mines-paristech.archives-ouvertes.fr/hal-01417184

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Background Experimental evidence suggests that developmental exposure to persistent organic pollutants (POP) and to some non persistent pesticides may disrupt metabolic regulation of glucose metabolism and insulin secretion, and thereby contribute to the current epidemic of obesity and metabolic disorders. Quasi-experimental situations of undernutrition in utero have provided some information. However, the evidence in humans concerning the role of the prenatal environment in these disorders is contradictory, and little is known about long-term outcomes, such as type 2 diabetes, of prenatal exposure. Objectives Our aim was to evaluate the effects of prenatal exposure to POP and organophosphate pesticides on fetal markers of glucose metabolism in a sample of newborns from the Pelagie mother–child cohort in Brittany (France). Methods Dialkylphosphate (DAP) metabolites of organophosphate pesticides were measured in maternal urine collected at the beginning of pregnancy. Cord blood was assayed for polychlorinated biphenyl congener 153 (PCB153), p,p′-dichlorodiphenyl dichloroethene (DDE) and other POP. Insulin and adiponectin were determined in cord blood serum (n=268). Results A decrease in adiponectin and insulin levels was observed with increasing levels of DDE, but only in girls and not boys. Adiponectin levels were not related to the concentrations of other POP or DAP metabolites. Decreasing insulin levels were observed with increasing PCB153 concentrations. Insulin levels increased with DAP urinary levels. Additional adjustment for BMI z-score at birth modified some of these relations. Conclusions Our observations bring support for a potential role of organophosphate pesticides and POP in alterations to glucose metabolism observable at birth
ISSN: 0013-9351

hal-01259218
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259218
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259218/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01259218/file/Prenatal%20exposure%20to%20persistent%20organic%20pollutants%20and%20organophosphate%20pesticides%2C%20and%20markers%20of%20glucose%20metabolism%20at%20birth.pdf
DOI : 10.1016/j.envres.2016.01.005

Éditeur(s) : HAL CCSD
Résumé : International audience
Background. In a French large population-based case-control study we investigated the dose-response relationship between lung cancer and occupational exposure to diesel motor exhaust (DME), taking into account asbestos exposure. Methods. Exposure to DME was assessed by questionnaire. Asbestos was taken into account through a global indicator of exposure to occupational carcinogens or by a specific JEM. Results. We found a crude dose response relationship with most of the indicators of DME exposure, including with the cumulative exposure index. All results were affected by adjustment for asbestos exposure. The dose response relationships between DME and lung cancer were observed among subjects never exposed to asbestos. Conclusions. Exposure to DME and to asbestos is frequently found among the same subjects, which may explain why dose-response relationships in previous studies that adjusted for asbestos exposure were inconsistent.
Journal of Cancer Epidemiology

hal-01205352
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01205352
DOI : 10.1155/2015/879302
PUBMED : 26425123

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
The natural history of pulmonary Langerhans cell histiocytosis (PLCH) has been unclear due to the absence of prospective studies. The rate of patients who experience an early progression of their disease is unknown. Additionally, conflicting effects of smoking cessation on the outcome of PLCH have been reported. In this prospective, multicentre study, 58 consecutive patients with newly diagnosed PLCH were comprehensively evaluated over a two-year period. Our objectives were to estimate the incidence of early progression of the disease and to evaluate the impact of smoking status on lung function outcomes. Lung function deterioration was defined as a decrease of at least 15% in FEV1 and/or FVC and/or DLCO, compared with baseline values. At each visit, smoking status was recorded based on the patients' self-reports and urinary cotinine measurements that were blinded for the patients. The cumulative incidence of lung function outcomes over time was estimated using the non-parametric Kaplan-Meier method. Multivariate Cox models with time-dependent covariates were used to calculate the hazards ratios of the lung function deterioration associated with smoking status with adjustment for potential confounders. The cumulative incidence of lung function deterioration at 24 months was 38% (22% for FEV1 and DLCO, and 9% for FVC). In the multivariate analysis, smoking status and PaO2 at inclusion were the only factors associated with the risk of lung function deterioration. The patients' smoking statuses markedly changed over time. Only 20% of the patients quit using tobacco for the entire study period. Nevertheless, being a non-smoker was associated with a decreased risk of subsequent lung function deterioration, even after adjustment for baseline predictive factors. By serial lung computed tomography, the extent of cystic lesions increased in only 11% of patients. Serial lung function evaluation on a three- to six-month basis is essential for the follow-up of patients with recently diagnosed PLCH to identify those who experience an early progression of their disease. These patients are highly addicted to tobacco, and robust efforts should be undertaken to include them in smoking cessation programs. ClinicalTrials.gov: No: NCT01225601 .
ISSN: 1750-1172

hal-01146047
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01146047
PUBMED : 25887097
DOI : 10.1186/s13023-015-0249-2

Éditeur(s) : HAL CCSD International Medical Press
Résumé : International audience
Background: Although the role of clinical/biological factors associated with mortality has already been explored in HIV-infected patients on antiretroviral therapy (ART), to date little attention has been given to the potential role of social vulnerability. This study aimed to construct an appropriate measure of social vulnerability and to evaluate whether this measure is predictive of increased mortality risk in ART-treated patients followed up in the ANRS CO8 APROCO-COPILOTE cohort.Methods: The cohort enrolled 1,281 patients initiating a protease inhibitor-based regimen in 1997–1999. Clinical/laboratory data were collected every 4 months. Self-administered questionnaires collected psycho-social/behavioural characteristics at enrolment (month [M] 0), M4 and every 8–12 months thereafter. A multiple correspondence analysis using education, employment and housing indicators helped construct a composite indicator measuring social vulnerability. The outcome studied was all-cause deaths occurring after M4. The relationship between social vulnerability and mortality, after adjustment for other predictors, was studied using a shared-frailty Cox model, taking into account informative study dropout.Results: Over a median (IQR) follow-up of 7.9 (3.0–11.2) years, 121 deaths occurred among 1,057 eligible patients, corresponding to a mortality rate (95% CI) of 1.64 (1.37, 1.96)/100 person-years. Leading causes of death were non-AIDS defining cancers (n=26), AIDS (n=23) and cardiovascular diseases (n=12). Social vulnerability (HR [95% CI] =1.2 [1.0, 1.5]) was associated with increased mortality risk, after adjustment for other known behavioural and bio-medical predictors.Conclusions: Social vulnerability remains a major mortality predictor in ART-treated patients. A real need exists for innovative interventions targeting individuals cumulating several sources of social vulnerability, to ensure that social inequalities do not continue to lead to higher mortality.
ISSN: 1359-6535

hal-01299300
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01299300
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01299300/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01299300/file/Twelve-year%20mortality%20in%20HIV-infected%20patients_accepted.pdf
DOI : 10.3851/IMP2960

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: Few studies have considered using environmental amenities to explain social health inequalities.Nevertheless, Green spaces that promote good health may have an effect on socioeconomic health inequalities. In developed countries, there is considerable evidence that green spaces have a beneficial effect on the health of urban populations and recent studies suggest they can have a positive effect on pregnancy outcomes. To investigate the relationship between green spaces and the spatial distribution of infant mortality taking account neighborhood deprivation levels. METHODS: The study took place in Lyon metropolitan area, France. All infant deaths that occurred between 2000 and 2009 were geocoded at census block level. Each census block was assigned greenness and socioeconomic deprivation levels. The spatial--scan statistic was used to identify high risk cluster of infant mortality according to these neighborhood characteristics. RESULTS: The spatial distribution of infant mortality was not random with a high risk cluster in the south east of the Lyon metropolitan area (p<0.003). This cluster disappeared (p=0.12) after adjustment for greenness level and socioeconomic deprivation, suggesting that these factors explain part of the spatial distribution of infant mortality. These results are discussed using a conceptual framework with 3 hypothetical pathways by which green spaces may have a beneficial effect on adverse pregnancy outcomes: (i) a psychological pathway, (ii) a physiological disruption process and (iii) an environmental pathway. CONCLUSIONS: These results add some evidence to the hypothesis that there is a relationship between access to green spaces and pregnancy outcomes but further research is required to confirm this.
BMC Pregnancy and Childbirth

hal-00876083
https://hal.archives-ouvertes.fr/hal-00876083
https://hal.archives-ouvertes.fr/hal-00876083/document
DOI : 10.1186/1471-2393-13-191

Éditeur(s) :  :
Siècle(s) traité(s) : 19
Droits : Domaine public
Provenance : Collectivité territoriale de Martinique. Bibliothèque Schoelcher
Permalien : http://www.manioc.org/patrimon/SCH13244
SCH13244